In line with the abovementioned decrease in C4, serum concentrations of the primary unconjugated BA cholate (CA) appeared lower in NASH-HCC as compared to NASH-non-HCC, whereas chenodeoxycholic acid (CDCA) levels were slightly increased in patients, with even higher levels in Nc and NHc (Table 2). Here, C4A is linked to hepatocellular carcinoma.