In this context, expression of calcium permeable (CP) AMPARs in the process of homeostatic scaling (Clem et al, 2010) as well as in maladaptive plasticity associated with cocaine addiction (Wolf & Ferrario, 2010; Luscher & Malenka, 2011) and oxygen–glucose depletion (Dixon et al, 2009) has been shown to involve PICK1. This evidence concerns the gene PICK1 and cocaine dependence.