The mean decreases in leptin (–15.8%, SD 29.9, vs 7.2%, SD 35.9, P=.01), insulin (–4.4%, SD 35.2, vs 15.4%, SD 35.1, P=.048), and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (–7.1%, SD 35.1, vs 14.4%, SD 41.2, P=.04) were significantly greater in the digital CBT group than in the control group. This evidence concerns the gene INS and Insulin resistance.