Supplementary Fig. 4e shows loss of SMA staining surrounding a representative progressed PDX DCIS MIND xenograft (high BCL9/PS-727-STAT3 co-expressing lesion) compared to a representative non-progressed PDX DCIS MIND xenograft (low BCL9/PS-727-STAT3 co-expressing) that showed an intact SMA layer. This evidence concerns the gene STAT3 and ductal breast carcinoma in situ.