BCL9 and cancer: While, we have demonstrated a significant association between enhancer sequences that are co-enriched with BCL9 and STAT3 and regulation of targets involved in cancer progression, future studies should address whether the predicted enhancers are functionally active by studies such as ATAC-Seq (Assay for Transposase-Accessible Chromatin using sequencing or open chromatin), lentiviral enhancer reporter constructs (i.e., LentiMPRA)45,46 and by HiChIP47.