PRKN(exon rearrangements), LRRK2(G2019S), GBA (L444P, N370S), and CHCHD2(P2L) appear to be the most penetrant mutations, increasing the chances of getting PD symptoms by up to a factor 14, 10, 8 and 5, respectively (Fig. 2c). This evidence concerns the gene PRKN and Parkinson disease.