LRRK2 and Parkinson disease: PRKN(exon rearrangements), LRRK2(G2019S), GBA (L444P, N370S), and CHCHD2(P2L) appear to be the most penetrant mutations, increasing the chances of getting PD symptoms by up to a factor 14, 10, 8 and 5, respectively (Fig. 2c).