Even after adjustment for age, gender, smoking, hypertension, diabetes, FBG, BUN, Cr, UA, CRP, PLT, FIB, INR, TC, TG, HDL-C, LDL-C and Lpa, multivariate logistic regression analysis also revealed that plasma exosome-encapsulated SOCS2-AS1 level was the independent protective factor for CAD (Table 3, model1–model6). This evidence concerns the gene LPA and hypertensive disorder.