INS and Abdominal obesity: Interestingly, there are some mi-RNAs (-146a,−155) that were associated with various metabolic comorbidities (type 2 diabetes mellitus, abdominal obesity, resistance to insulin) among patients with HF and adverse cardiac remodeling (70, 108), but the role of endothelial cell-derived EVs in transportation of these molecules still needs to be confirmed further.