IGF1 and cardiac hypertrophy: There is strong evidence that micro-RNA-1 and mi-RNA−155 via interaction with free fatty acids cardiac binding protein FABP3, insulin-like growth factor-1 (IGF-1), IGF-1 receptor, and twinfilin-1 regulate cardiac myocyte free fatty acids uptake, provide proliferative response, and mediate myocardial hypertrophy (62, 63).