In line with these in vitro experiments, suppression of HSP60 in hepatoma xenograft mice models using jet polyethylenimine mediated shHSP60 delivery systems (PEI/shHSP60 complexes) resulted in significant reduction of tumor volumes and weights in the shHSP60 group compared to the control group (Huang et al., 2018). Here, HSPD1 is linked to neoplasm.