In addition, an increase in chemokine ligand 2 (CCL2) mRNA content was observed in EVs from kidneys of mice exposed to lipopolysaccharide and in uEVs of rats with 5/6 nephrectomy, experimental models of AKI and chronic kidney disease (CKD), respectively (Lv et al., 2018). Here, CCL2 is linked to chronic kidney disease.