Considering the fact that lncRNA-MIAT is involved in the pathogenesis of DCM and IL-17-mediated cardiac interstitial fibrosis is a major feature of DCM, we questioned if lncRNA-MIAT can regulate IL-17 expression, contributing to the development of cardiac interstitial fibrosis, and ultimately onset of DCM. This evidence concerns the gene IL17A and familial dilated cardiomyopathy.