In previous reports, we showed that 1A-116 was able to inhibit Rac1-GEF interactions reducing Rac1 activation levels and showing anti-proliferative effects on different cancer cell lines (Figure 1B; Cardama et al., 2014a, b; Cabrera et al., 2017; Gonzalez et al., 2017) but not in COS-1 cells used in the luciferase assays (Figure 1C). The gene discussed is RAC1; the disease is cancer.