CFTR and cystic fibrosis: In diseases affecting predominantly conductive airways, such as cystic fibrosis, targeted de-epithelialization of the conductive airways could allow removal of the mutant transmembrane conductance regulator (CFTR) epithelial cells and replacement with normal human bronchial epithelial cells or iPSCs where CFTR mutation is corrected (Cutting, 2015; Berical et al., 2019).