A more recent study involving 660 apparently healthy adolescents, showed that those with low muscle mass (into the first quartile) had higher cardiometabolic risk (higher values of BMI z-score, WC, systolic BP, diastolic BP, TG, TC/HDL-C, insulin, HOMA-IR, and MetS z-score) than adolescents in the other quartiles regardless of nutritional status (17). The gene discussed is INS; the disease is metabolic syndrome.