Some studies indicated the role of Insertion/ Deletion (I/D) polymorphism at -2549 position of the promoter region in VEGF gene which is associated with several disorders such as breast cancer (8), end stage renal disease (ESRD) (11), peripheral arterial disease (PAD) in type 2 diabetes mellitus (T2DM) (12), diabetic nephropathy (DN) (13, 14) and retinopathy (DR) (15, 16), asthma (17), prostate cancer (18), and Behcet's disease (BD) (19) in which angiogenesis may be implicated. The gene discussed is VEGFA; the disease is retinal disorder.