CD8A and infection: In these structures, tissue-infiltrating antiviral CD8+ T cells congregate at infected cells to prevent intra-tissue virus spread, thereby confining the infection to few tissue cells with no apparent histopathology (Alterio de Goss et al., 1998; Holtappels et al., 1998; Podlech et al., 2000; Sacher et al., 2008; Thomas et al., 2015).