Whole-exome sequencing (WES) data analysis of 206 sarcomas of different histotypes identifies TP53, ATRX, and RB1 significantly mutated genes across sarcoma histotypes where TP53 mutations were most prevalent in leiomyosarcoma and RB1 mutations were seen in leiomyosarcoma, undifferentiated pleomorphic sarcoma, and myxofibrosarcoma (6). This evidence concerns the gene RB1 and leiomyosarcoma.