↘ Angiogenesis and tumor growth (ocular, lung, breast, oral squamous cell, esophageal carcinoma, gastric, ovarian, pancreatic, prostate, and colorectal cancer (28)↘ VEGF-A/VEGFR-1-2 signaling pathway in squamous cell carcinoma (29)↗ Apoptosis in cancer cell and EC through bcl-2bcl-xl/bax ratio modulation (30)↘ Caspase 8 and 9 activation in EC (27). The gene discussed is CASP8; the disease is colorectal cancer.