↘ Tumor growth (melanoma, glioma, osteosarcoma, breast, colon, prostate and lung cancer, gastric, hepatocellular and squamous cell carcinoma (37–40)↘ FAK/PI3K/Akt pathway and ↘ MMP-2 in tumor cells (37, 38). This evidence concerns the gene PTK2 and osteosarcoma.