↗ Angiogenesis (63) and tumor growth in melanoma models (62, 64, 65)↗ MT1-MMP, ↗ PI3K/Akt/NO synthase, ↗ NO/cGMP/Erk1/2 pathways in EC (66)↗ IL-1β through NF-κB pathway in melanoma cell (67)↗ MMP and plasminogen activation cascades in cancer cells. This evidence concerns the gene PLG and melanoma.