Multiple factors, including advancing age, male sex, obesity, heart failure, obstructive sleep apnea, anxiety, systemic arterial hypertension, and biomarkers such as N-terminal pro-B-type natriuretic peptide (NT-proBNP), have been identified as factors correlated with AF development [12–15]. This evidence concerns the gene NPPB and obesity due to melanocortin 4 receptor deficiency.