Interestingly, a relatively diverse MAPK1 mutation pattern and a relatively higher mutation rate of MAPK1 (5.7%; 6/105 fresh frozen tumors from 103 unique individuals) were identified in our small Hong Kong HNSCC cohort (by targeted sequencing, >500 × mean depth covering 92.2% of all nine MAPK1 exons). Here, MAPK1 is linked to head and neck squamous cell carcinoma.