IFNA1 and systemic lupus erythematosus: Continuous inflammatory production of interferon-alpha (IFN-α) and subsequent increased expression of IFN-α-regulated genes, referred as IFN signature, due to activation of plasmacytoid dendritic cells by immune complexes, consisting of autoantibodies in combination with deoxyribonucleic acid- (DNA-) or ribonucleic acid- (RNA-) containing autoantigens, have been reported in SLE patients.