DDAH2 and atherosclerosis: Given the evident role of TNF in atherosclerosis and RA pathogenesis and its inhibitory effect on DDAH leading to ADMA accumulation, a beneficial effect of TNF inhibition has been postulated; however, results of conducted studies did not demonstrate a consistent decrease in ADMA levels with subsequent improvement in vascular morphology and function suggesting that the ADMA level does not seem to be a straightforward indicator of endothelial dysfunction and subclinical atherosclerosis in rheumatic diseases.