CRP and endothelial dysfunction: It has been demonstrated that baseline disease status (mainly elevated erythrocyte sedimentation rate (ESR) and also CRP) and cumulative inflammatory burden (6 years of follow-up) had a positive correlation with current ADMA levels as—according to authors—patients with longer periods of uncontrolled disease are more prone to develop endothelial dysfunction due to the higher cumulative inflammatory burden on the vasculature [165].