The relevant literatures also revealed that FGF1, FGF2, MAPT, CHRM2, CA2, CHRM1, STAT3, AR, CYP19A1, HSD11B1, NR1H3, HMGCR, ESR2, ESR1 and VDR may be involved in the pathogenesis of AD. The gene discussed is MAPT; the disease is Alzheimer disease.