The relevant literatures also revealed that FGF1, FGF2, MAPT, CHRM2, CA2, CHRM1, STAT3, AR, CYP19A1, HSD11B1, NR1H3, HMGCR, ESR2, ESR1 and VDR may be involved in the pathogenesis of AD. This evidence concerns the gene CHRM2 and Alzheimer disease.