FJG module mainly regulates butanoate metabolism, osteoclast differentiation, cytokine-cytokine receptor interaction, and other pathways; the SP module mainly controls amyotrophic lateral sclerosis (ALS), p53 signaling pathway, apoptosis, and biosynthesis of unsaturated fatty acids, etc. SP-FJG chiefly controls autoimmune thyroid diseases, type 1 diabetes mellitus, etc. FJG and SP-FJG coregulation pathway is the herpes simplex infection. Here, TP53 is linked to herpes simplex infectious disease.