UCHL5 and rectal cancer: In addition, positive cytoplasmic UCHL5 indicated that patients with GC had smaller primary lesions and TNM stage I-II, and predicted longer survival time [24], while positive nuclear UCHL5 implied a better prognosis of patients aged over 65 years or with lymph-node positivity [25]; at the same time, high and undetectable UCHL5 levels were related to extended overall disease-specific survival in the lymph-node positivity rectal cancer patients [26].