UCHL5 and metastatic malignant neoplasm in the lymph nodes: However, similar to DRAIC, UCHL5 has been corroborated to play conflicting biological effects in cancers: The superior expression of UCHL5 was observed in esophageal squamous cell carcinoma tissues, and was correlated with TNM stage, lymph node metastasis, recurrence rate and poor prognosis [21].