TGFB1 and Familial prostate cancer: In another study, PlncRNA-1 was found to enhance cell proliferation and induce EMT in prostate cancer through reciprocal regulation of AR (Cui et al., 2013; Fang et al., 2016), Her-2 (Yang et al., 2017), and TGF-β (Jin et al., 2017) signaling pathways.