In melanoma, CD73 expression is influenced by sample type (e.g., primary, metastatic, or relapse tissue); therapy treatment; and presence of activating MAPK (e.g., BRAF) mutations, mitogenic and inflammatory signals [e.g., hepatocyte growth factor (HGF) and TNF-α], and necrosis (41, 42). The gene discussed is BRAF; the disease is melanoma.