FOXP3 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome: In addition, scurfy mice that possess a spontaneous recessive mutation in Foxp3 develop a lymphoproliferative disorder that parallels IPEX (immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome in humans, which is also caused by mutations in Foxp3 (74).