Remarkably, LCA and HDCA were found to be decreased in serum or intestine of animals with hepatic steatosis (Tang et al., 2019; Ushiroda et al., 2019), while dietary HDCA could exert hypolipidemic effects by reducing FXR antagonist BAs in enterohepatic tissues (Watanabe and Fujita, 2014). Here, NR1H4 is linked to fatty liver disease.