Remarkably, LCA and HDCA were found to be decreased in serum or intestine of animals with hepatic steatosis (Tang et al., 2019; Ushiroda et al., 2019), while dietary HDCA could exert hypolipidemic effects by reducing FXR antagonist BAs in enterohepatic tissues (Watanabe and Fujita, 2014). Here, NR1H4 is linked to Hepatic steatosis.