SLC5A2 and heart failure: In fact, by using SGLT2 inhibitors, the risk of major adverse cardiovascular events was significantly decreased [relative risk (RR) 0.84, 95% CI 0.75–0.95, p = 0.006], similar to cardiovascular death (RR 0.63, 95% CI 0.51–0.77, p < 0.0001) and heart failure (RR 0.65, 95% CI 0.50–0.85, p = 0.002).