AngII infusion impaired both Wt-AngII and Tg-AngII rats in the MWM adaptation of a delayed match-sample test, a spatial task that tests working memory and behavioral flexibility, consistent with the clinical studies on the cognitive effects of hypertension (Raz et al., 2003; Vicario et al., 2005; Li et al., 2016). The gene discussed is AGT; the disease is hypertensive disorder.