AGT and hypertensive disorder: For 8 weeks, 8–10 month old male wildtype and transgenic rats were infused with either normal saline (Wt and Tg rats) or Angiotensin II (AngII; Wt-AngII and Tg-AngII rats) to elevate blood pressure and model the effects of hypertension (Crowley et al., 2006; Osborn et al., 2011; Lohmeier, 2012).