MAPT and Alzheimer disease: The relationship between AD and vascular pathology has given rise to the neurovascular hypothesis of AD (Zlokovic, 2005, 2011; Kisler et al., 2017), which proposes that cerebrovascular dysregulation, including the effect of systemic hypertension on the brain, disrupts amyloid and tau protein homeostasis, leading to neuronal injury and cognitive impairment.