AGT and Hypertension: As both hypertension and high levels of amyloid activate both astrocytes and microglia (Vitaioli et al., 2004; Tomassoni et al., 2010; Prokop et al., 2013; Dunn and Nelson, 2014; Shen et al., 2015; von Bernhardi et al., 2015; Frost and Li, 2017; Wang et al., 2018), we expected the greatest amount of glial activity in the comorbid Tg-AngII rats.