Laje et al. (2012) proposed that alterations in BDNF function can impact ketamine’s antidepressant effects through a small trial investigated ketamine treatment outcomes in patients with major depression carrying either the functional BDNF val66val allele against met carriers found an increased antidepressant response to ketamine in individuals with the Val/Val than met carriers. This evidence concerns the gene BDNF and major depressive disorder.