Several lines of evidence have suggested that there is an increase in SphK2 activity in the frontal cortex while SphK2 expression inhibition was observed in the temporal cortex and hippocampus of AD brains (Takasugi et al., 2011; Maceyka et al., 2012; Asle-Rousta et al., 2013). This evidence concerns the gene SPHK2 and Alzheimer disease.