These data are consistent with previous findings that APC suppressed microglial activation in an animal model of amyotrophic lateral sclerosis (ALS), a protective effect that was shown to correlate with downregulation of superoxide dismutase-1 (SOD-1) in both microglial cells and neurons (Zhong et al., 2009). This evidence concerns the gene APC and amyotrophic lateral sclerosis.