Recent work has shed light on the signaling mechanisms underpinning APC’s vasculoprotective influence by revealing that APC promoted vascular integrity of an endothelial monolayer in vitro and that infusion of APC enhanced vascular barrier integrity in a sepsis model in wild-type mice but not in transgenic mice deficient in protease activated receptor-1 (PAR-1) mice (Schuepbach et al., 2009). Here, APC is linked to Sepsis.