The criteria are as follows: (1) encephalopathy with seizures, myoclonus, hallucinations, or stroke-like episodes; (2) subclinical or mild overt thyroid disease (usually hypothyroidism); (3) normal findings or non-specific abnormalities shown by brain MRI; (4) presence of thyroid antibodies in the serum (thyroid peroxidase, thyroglobulin); (5) absence of well-characterized neuronal antibodies in the serum and CSF; and (6) reasonable exclusion of alternative causes. The gene discussed is TG; the disease is hypothyroidism.