AKT1 and neoplasm: Meanwhile, our results of immunohistochemistry documented that in contrast to the agomir-NC group, tumor of mice in the agomir-miR-135b group had reduced JADE-1 positive expression rate and enhanced positive expression rates of phosphorylated AKT and phosphorylated mTOR while the antagomir-miR-135b exhibited the opposite trends as compared to the antagomir-NC (p < 0.05).