Furthermore, the proinflammatory cytokines IL-6, TNF-α, IFN-γ, and IL-12 play such an important inductor of inflammation in disorders such as severe/uncontrolled asthma, Alzheimer's disease, and rheumatoid arthritis and may be considered a predictive factor for treatment failure [24]. This evidence concerns the gene TNF and early-onset autosomal dominant Alzheimer disease.