TNF and Alzheimer disease: Previous studies showed that miR‐146a was an anti‐inflammatory miRNA with a compensatory up‐regulation in psoriasis.13 It was involved in TNF‐α signalling and the NF‐κB pathway.25 MiR‐146a expression was up‐regulated in keratinocytes and skin of AD patients.26 Transfection of miR‐146a decreased the expression of multiple pro‐inflammatory factors, including AD‐associated and IFN‐γ‐inducible genes CCL5, CCL8 and ubiquitin D (UBD) in keratinocytes and in a mouse model of AD.