HAS3, a damage‐associated positive regulator of keratinocyte proliferation and migration, was identified as the direct target of miR‐10a‐5p.20 These evidence collectively suggested that the aberrant up‐regulation of miR‐10a‐5p in AD could impair keratinocyte proliferation that is important for maintaining the skin barrier function. Here, HAS3 is linked to Alzheimer disease.