Under conventional housing tumor development in the large bowel of DKO mice was comparable to that of SPF housed mice with an increase to 78% in DKO mice compared to 8% in MSH2loxP/loxP Vil‐cre mice (P = .002) and 40% in IL‐10−/− mice (Figure 1B), indicating that intestinal tumorigenesis in DKO mice was independent of housing conditions. Here, IL10 is linked to neoplasm.