Multivariate Cox regression analysis was performed when the cohort was stratified based on MX1 expression, in low MX1 protein expression cohort, adjuvant chemotherapy was independent predictor of shorter BCSS (p = 0.017; HR = 0.493; 95% CI = 0.276–0.879) regardless of, tumour grade, nodal stage, tumour size, HER2 status and basal phenotype (Table 5). This evidence concerns the gene MX1 and neoplasm.