At the same time, they also confirmed that CYP3A5 over-expression in hepatocellular carcinoma cells inhibits the metastasis and invasion of cancer cells in vivo and in vitro, via manipulating ROS/mTORC2/p-AKT (S473) signaling pathway and limiting MMP2/9 function [25, 27]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.