High levels of CD8+ T cells were found in the resected lymph node metastasis of patient 1; the resected liver metastasis of patient 2 showed a 20 times lower CD8+ T cell density both by RNAseq and by IHC (Fig. 3b, c, Supplementary Fig. 2). Here, CD8A is linked to metastatic malignant neoplasm in the lymph nodes.