CD274 and neoplasm: Consistently, this blocking antibody inhibited tumor growth in Pd-l1 depleted xenografts restored with the wildtype Pd-l1 or the ake mutant, regardless of the fact that xenograft tumors expressing wildtype Pd-l1 grew much faster than tumors expressing the ake mutant (Fig. 3j and Supplementary information, Fig. S5a, b).