CD274 and neoplasm: To further test whether the AKE mutation affects tumor growth and the immune suppression function of PD-L1, we injected mouse B16F10 cells expressing control shRNA, mouse Pd-l1 shRNA, mouse Pd-l1 shRNA plus shRNA resistant wildtype Pd-l1, or mouse Pd-l1 shRNA plus shRNA resistant ake Pd-l1 into immunocompetent C57BL/6 mice.