Loss-of-Gprc6a function in hepatocytes resulted in several metabolic abnormalities in Gprc6aLiver-cko mice, including hyperglycemia, reduced serum insulin levels, increased circulating concentrations of free fatty acids and cholesterol, impaired glucose and pyruvate tolerance tests, and increased fat and decreased glycogen content in the liver (Fig. 8). The gene discussed is INS; the disease is Hyperglycemia.