GPRC6A and Hyperglycemia: The results, which are like the above studies in Hepa1c1c7 cells expressing endogenous Gprc6a before and after siRNA knockdown (Fig. 1), show GPRC6A-dependent increases in glucose production by Ocn and T. Thus, the fasting hyperglycemia in Gprc6aLiver-cko is not due to enhanced gluconeogenesis or insulin resistance.