AMOTL1 and metabolic disease: Thus, it can be speculated that also the remaining 13 genes (e.g. angiomotin like 1, Amotl1; proline rich 11, Prr11; or schlafen5, Slnf5 and Slnf8) may also be relevant and might be involved in metabolic diseases, which has to be evaluated in the future (Table 1).