Similarly, we studied the effect of ricolinostat on other tumor cell lines but did not observe an increase in CD38 expression after ricolinostat in lymphoma or leukemia cell lines (Supplementary Figs. 5 and 6a, b), indicating that upregulation of CD38 by ricolinostat is a specific effect in MM cells. Here, CD38 is linked to Miyoshi myopathy.