miR-142-3p (80% sEV signal), was recently shown by another group to be selectively packaged in sEVs by a panel of oral squamous cell carcinoma cell lines, which resulted in lower intra-cellular levels and promoted malignant changes in these cells via increase of TGFBR1 expression51. Here, TGFBR1 is linked to oral cavity squamous cell carcinoma.