Interestingly, increased IR was also found in cancer SC (CSC)-enriched PSA−/lo cell population isolated from LAPC9 xenografts27, basal-like LNCaP cells depleted of TP53 and RB121, and LNCaP-CRPC cells that survived long-term Enza treatment28 (Fig. 2d). The gene discussed is TP53; the disease is cancer.