Also, re-analysis of a recent RNA-seq dataset (GSE71797)41 confirmed that in response to R1881 (24~48 h), activated AR signaling reshaped the AS landscape in three AR+ PCa cell models (i.e., LNCaP, VCaP, and 22Rv1) (Supplementary Fig. 7d). Here, AR is linked to posterior cortical atrophy.