Recent genomic sequencing has revealed global mutational landscapes of PCa during development and progression4,16,19,39,43–47, almost all of which focused their analysis on known PCa-related genes and pathways (e.g., AR, PTEN/PI3K, TP53, RB1, DNA repair, ETS fusion), whereas alterations in SRGs were overlooked due to a low mutation frequency at individual gene level. This evidence concerns the gene TP53 and posterior cortical atrophy.