We also observed an overall increase (e.g., 8% to 14% for KHDRBS3, 7–17% for ESRP1) and decrease (e.g., 18–7% for ENOX1, 16–6% for WBP4) in the frequencies of amplified and deleted genes, respectively, in CRPC vs. pri-PCa (Fig. 4a, b). Here, ESRP1 is linked to posterior cortical atrophy.