MYC and posterior cortical atrophy: As Myc overexpression and function represent a critical early oncogenic driver of PCa, many SRGs are co-amplified with the MYC gene and Myc-driven lymphomas are susceptible to spliceosome interference10, we treated the Myc-driven murine PCa (Hi-Myc tumors) with E7107 (Fig. 10a) and observed significant inhibition by E7107 of Hi-Myc tumors (Fig. 10b).