ESRP1 and posterior cortical atrophy: To functionally demonstrate the role of SRGs, we knocked down ESRP1 and KHDRBS3 in PC3 cells, as both genes were amplified and overexpressed in pri-PCa and CRPC-Ad (Figs. 4a, b and 5, and Supplementary Data 4) and predictive of worse outcome in PCa patients (Fig. 6a).