TP53 and cancer: On the contrary, cancer cells expressing other hotspot GOF p53 mutations, such as LUSC cells H596 (p53G245C) and ChaGo-k-1 (p53C275F); lung adenocarcinoma H1417 (p53R175L) and H1975 (p53R273H); breast carcinoma SK-BR-3 (p53R175H), HCC70 (p53R248Q), BT-549 (p53R249S) and MDA-MB-468 (p53R273H); pancreatic carcinoma MIA-Paca-2 (p53R248W) and PANC-1 (p53R273H); did not show increased in apoptotic markers when belinostat was combined with cisplatin (Fig. 3b, Supplementary Fig. 3A, B).