Interestingly, similar observation was observed in other cancer types harboring Arg158 p53 mutations, including H441 (lung adenocarcinoma, p53R158L), H661 (lung large cell carcinoma, p53R158L), and H747 (colorectal carcinoma, p53R158L) (Fig. 3a, b). This evidence concerns the gene TP53 and lung large cell carcinoma.