The wtp53-p65 relationship was illustrated experimentally in colon cancer cells HCT116 p53 wild-type/null pairs52, where drug combination induced p65 nuclear translocation in wild-type (HCT116+/+) but not in null (HCT116−/−) cells (Supplementary Fig. 12A–D). This evidence concerns the gene RELA and malignant colon neoplasm.