Whether these molecular patterns of TDP-43 pathology represent types of LATE-NC and, thereby, are features of one disease entity (LATE) or whether they represent a spectrum of late-life neuropathologies in AD ranging from ADTDP- to ADTDP + CTF and finally ADTDP + FL with molecular similarities to FTLD-TDP needs to be explored in the future. This evidence concerns the gene TARDBP and Alzheimer disease.