TARDBP and Alzheimer disease: Given the hierarchical detectability of first pTDP-43409 and pTDP-43409/410 in cases with LATE-NC stages 1–2 and second other TDP-43 epitopes in ADTDP + FL cases with LATE-NC stages 2 and 3, one could hypothesize that TDP-43 aggregates in AD undergo maturation changes similar to Aβ aggregates [56].