Risk prediction will also benefit from combining GRS with other risk factors, such as age, environmental exposures and biomarkers; this has been shown in studies of prostate cancer, where prediction models based on prostate-specific antigen alone were significantly improved when combined with GRSs and clinical variables (e.g. age, family history, previous prostate biopsy and prostate exam) [65]. The gene discussed is KLK3; the disease is prostate cancer.