In sequencing studies of schizophrenia, three genes (SETD1A, RBM12, and SLC6A1) have been robustly associated with RCVs [5, 39, 40]; however, the strong excess of LoF variants in constrained genes in schizophrenia suggests that additional single-gene associations will emerge from larger NGS studies. Here, SETD1A is linked to schizophrenia.