According to histological subtypes, the most frequent mutated gene was KMT2D (7/34, 20.6%) in PTCL-NOS, TET2 (9/18, 50.0%) in AITL, and DNMT3A (2/7, 28.6%) in ALCL-ALK negative. Here, KMT2D is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.